منابع مشابه
Dystroglycan Versatility
cytoskeleton, thus stabilizing the muscle as it alternately Martin E. Hemler Dana-Farber Cancer Institute contracts and relaxes. In particular, the a-dystroglycan protein binds to the extracellular matrix protein Boston, Massachusetts 02115 laminin-2, while b-dystroglycan spans the membrane and links directly to dystrophin, and other cytoskeletal proteins in the dystrophin family (Figure 1A). T...
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Mutations in PSEN1 and PSEN2 genes, encoding presenilin 1 (PS1) and presenilin 2 (PS2), respectively, cause autosomal-dominant Alzheimer’s disease (ADAD) (1, 2). The precise mechanism by which PS1 mutations lead to AD is under active investigation. Multiple theories have been suggested to explain the role of PS1 and PS2 mutations on AD pathogenesis, including the effects on γ-secretase activity...
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UNLABELLED It has recently been suggested that, similar to MRI, CT can be used to detect infarcts at high resolution by delayed myocardial contrast enhancement. In cardiac PET/CT, this ability to detect infarcts may increase the versatility and integrative potential of PET and CT study components. We sought to determine the feasibility of delayed CT-enhancement in the PET/CT environment and com...
متن کاملExpanding the Versatility of a More Accurate Accelerated Monte Carlo Simulation for 3D PET: Data Correction of PET Emission Scans
-Our Monte Carlo PET simulation for a 3D PET scan is able to simulate ~5 million coincidence events per minute per minute on 300MHz Sun dual processor workstation. This is over two orders of magnitude faster than most other available Monte Carlo simulations for 3D PET and is fast enough to be employed as a scatter correction for 3D PET imaging. We have improved the accuracy of our simulation of...
متن کاملExpanding the Versatility of Phage Display I: Efficient Display of Peptide-Tags on Protein VII of the Filamentous Phage
BACKGROUND Phage display is a platform for selection of specific binding molecules and this is a clear-cut motivation for increasing its performance. Polypeptides are normally displayed as fusions to the major coat protein VIII (pVIII), or the minor coat protein III (pIII). Display on other coat proteins such as pVII allows for display of heterologous peptide sequences on the virions in additio...
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ژورنال
عنوان ژورنال: Nature
سال: 2010
ISSN: 0028-0836,1476-4687
DOI: 10.1038/464357a